Schistosomiasis – IBHI Lab

May 12, 2023 • Partnership

Merck KGaA Officials visit the IBHI Laboratory

Site visit and riveting discussion at the IBHI Lab by Merck KGaA Global Health Institute officials, Dr Beatrice Greco and Dr Rana Afshar. The need for continued collaborative venture by endemic researchers and the intensification of bedside research was discussed amid presentations by Merck-funded fellows.

September 24, 2022 • meeting

IBHI Lab at the face to face meeting on Schistosomiasis, London, UK

Dr Nono participated in the Face to face schistosomiasis meeting from 22-23 September 2022 organized by the University of Dundee Drug Discovery Unit with high level officials of Merck, WHO, DNDi and Wellcome Trust to discuss on the best ways forward to new treatments against schistosomiasis.

February 24, 2022 • Non classé

Inauguration of the IBHI Unit in Cameroon by high-level officials from the Institute of Medical Research and Medicinal Plants studies in the presence of heads of the National Control Program for the Fight against Schistosomiasis and Intestinal Helminthiases, the Centre for Research in Infectious Diseases and EPICENTRE – MSF Cameroon

Dr Nono presented on the new Unit for the research on ImmunoBiology and Helminth Infections. The objectives, mission, vision and achievements so far. A project made possible with the support of Merck KgaA, The Uk Royal Society and the African Academy of Sciences.
23 February 2022

February 14, 2022 • Schistosomiasis Infection

Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses

Our latest research showing the impact of schistosomiasis on anti-viral vaccination is out in Plos Pathogens.

December 12, 2021 • Schistosomiasis Infection

Praziquantel Treatment of Schistosoma mansoni Infected Mice Renders Them Less Susceptible to Reinfection.

Nono JK, Mpotje T, Mosala P, Aziz NA, Musaigwa F, Hlaka L, Spangenberg T and Brombacher F. We report here, with experimental proof in a murine tractable model of high transmission, the added benefit that deworming with praziquantel might have for achieving elimination of schistosomiasis by fostering the development of resistance to reinfection in the […]

August 31, 2021 • Schistosomiasis Infection

Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon

We convincingly report on a negative association between plasma IL-33 levels and schistosomiasis infection and egg burden in school children from a polyparasitic schistosomiasis endemic area. A suggested potential of IL-33 as biomarker of schistosomiasis infection is proposed.

August 30, 2021 • Vaccine

Influence of schistosomiasis on host vaccine responses

Here, we review available evidence on the influence of transgenerational and direct Schistosoma parasite exposure on host immune responses to unrelated vaccines. In addition, we evaluate the potential of praziquantel (PZQ) treatment in restoring schistosomiasis-impacted vaccine responses