Dr Nono participated in the Face to face schistosomiasis meeting organized by the University of Dundee Drug Discovery Unit with high level officials of Merck, WHO, DNDi and Wellcome Trust to discuss on the best ways forward to new treatments against schistosomiasis.
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Dr Nono presented on the new Unit for the research on ImmunoBiology and Helminth Infections. The objectives, mission, vision and achievements so far. A project made possible with the support of Merck KgaA, The Uk Royal Society and the African Academy of Sciences.
23 February 2022
Our latest research showing the impact of schistosomiasis on anti-viral vaccination is out in Plos Pathogens.
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Nono JK, Mpotje T, Mosala P, Aziz NA, Musaigwa F, Hlaka L, Spangenberg T and Brombacher F. We report here, with experimental proof in a murine tractable model of high transmission, the added benefit that deworming with praziquantel might have for achieving elimination of schistosomiasis by fostering the development of resistance to reinfection in the […]
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We convincingly report on a negative association between plasma IL-33 levels and schistosomiasis infection and egg burden in school children from a polyparasitic schistosomiasis endemic area. A suggested potential of IL-33 as biomarker of schistosomiasis infection is proposed.
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Here, we review available evidence on the influence of transgenerational and direct Schistosoma parasite exposure on host immune responses to unrelated vaccines. In addition, we evaluate the potential of praziquantel (PZQ) treatment in restoring schistosomiasis-impacted vaccine responses
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